DR MANUELA RAFFATELLU -New insights on mucosal immunity to Enterobacteriaceae



Manuela Raffatellu is a Professor in the Department of Pediatrics at the University of California, San Diego School of Medicine. She received her M.D. at the University of Sassari, Italy, in 2000, then joined the laboratory of Dr. Andreas Bäumler as a postdoctoral fellow in 2002, first at Texas A&M University and then at the University of California, Davis. She started her own lab at the University of California, Irvine in 2008, then relocated to the University of California, San Diego in 2017. Her research focuses on Salmonella interaction with the mucosal immune response in the inflamed gut and with the intestinal microbiota. She is the recipient of several awards, including the IDSA ERF/NFID Astellas Young Investigator Award, the ICAAC Young Investigator Award from the American Society for Microbiology, and the Burroughs Wellcome Funds Investigator in the Pathogenesis of Infectious Disease Award.


The Raffatellu Lab’s primary research focus is to understand the complex interplays between gut pathogens, mucosal immunity, and the gut microbiota, with the long-term goal of discovering novel and effective therapeutic targets for controlling infection. Our studies generally focus on the host response to gut mucosal pathogens such as Salmonella enterica, and we aim to decipher how the mucosal response to infection is orchestrated, including which components are beneficial to the host and which are evaded or exploited by pathogens to cause disease. Indeed, components of the immune response often constitute double-edged swords: on one edge, they are necessary to contain an infection to the mucosa; on the other edge, they can be leveraged by pathogens to outcompete the microbiota and to colonize the host. In order to unravel these complex interactions, we use a multidisciplinary research approach at the interface between microbiology and immunology, and we collaborate with many experts in related fields.
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8 décembre 2023


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